Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Abstract Influenza A virus (IAV) causes pandemics and annual epidemics of severe respiratory infections. A better understanding of the molecular regulation in tissue and cells upon IAV infection is needed to thoroughly understand pathogenesis. We analyzed IAV replication and gene expression induced...

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Bibliographic Details
Main Authors: Wilhelm Bertrams, Katja Hönzke, Benedikt Obermayer, Mario Tönnies, Torsten T. Bauer, Paul Schneider, Jens Neudecker, Jens C. Rückert, Thorsten Stiewe, Andrea Nist, Stephan Eggeling, Norbert Suttorp, Thorsten Wolff, Stefan Hippenstiel, Bernd Schmeck, Andreas C. Hocke
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24792-4

Internet

https://doi.org/10.1038/s41598-022-24792-4

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