Synthesis of 2,2-difluoro-2-arylethylamines as fluorinated analogs of octopamine and noradrenaline

Synthesis of 2,2-difluoro-2-arylethylamines as fluorinated analogs of octopamine and noradrenaline

A series of 2,2-difluoro-2-arylethylamines was synthesized as fluorinated analogs of octopamine and noradrenaline with the expectation of bioisosteric OH/F exchanges. The syntheses of these compounds were performed by a Suzuki–Miyaura cross-coupling reaction of 4-(bromodifluoroacetyl)morpholine with...

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Bibliographic Details
Main Authors: Tarui Atsushi, Kamata Erika, Ebisu Koji, Kawai Yui, Araki Ryota, Yabe Takeshi, Karuo Yukiko, Sato Kazuyuki, Kawai Kentaro, Omote Masaaki
Format: Article
Language:English
Published: De Gruyter 2022-03-01
Series:Heterocyclic Communications
Subjects:
difluoroacetamide
fluorine analogue
suzuki–miyaura coupling
octopamine
noradrenaline
Online Access:https://doi.org/10.1515/hc-2022-0005

Internet

https://doi.org/10.1515/hc-2022-0005

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