Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation

Abstract Retinal ganglion cells (RGCs) axons are the signal carriers of visual information between retina and brain. Therefore, they play one of the important roles affected in many optic neurodegenerative diseases like glaucoma. Among the genetic risks associated with glaucoma, the E50K mutation in...

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Bibliographic Details
Main Authors: Mingying Hou, Zhengbo Shao, Shiqi Zhang, Xinna Liu, Pan Fan, Menglu Jiang, Yutong Zhao, Rong Xiao, Huiping Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04836-3