Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids

Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids

Non-alcoholic steatohepatitis (NASH) is known to progress to cirrhosis and hepatocellular carcinoma in some patients. Although NASH is associated with abnormal mitochondrial function related to lipid metabolism, mechanisms for the development and effective treatments are still unclear. Therefore, ne...

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Bibliographic Details
Main Authors: Mohamed Elbadawy, Kiwamu Tanabe, Haru Yamamoto, Yusuke Ishihara, Maria Mochizuki, Amira Abugomaa, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
organoids
fibrosis
NASH
mitochondria
ROS
DRP1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1243258/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1243258/full

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