Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers

Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers

Introduction: HER2 overexpression induces cancer aggression and frequent recurrences in many solid tumors. Because HER2 overproduction is generally followed by gene amplification, inhibition of protein–protein interaction (PPI) between transcriptional factor ELF3 and its coactivator MED23 has been c...

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Bibliographic Details
Main Authors: Soo-Yeon Hwang, Seojeong Park, Hyunji Jo, Seung Hee Seo, Kyung-Hwa Jeon, Seojeong Kim, Ah-Reum Jung, Chanju Song, Misun Ahn, Soo Yeon Kwak, Hwa-Jong Lee, Motonari Uesugi, Younghwa Na, Youngjoo Kwon
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Advanced Research
Subjects:
HER2 transcriptional downregulator
ELF3-MED23 interaction
Small molecule PPI inhibitor
Hotspot identification
Trastuzumab resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222001710

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http://www.sciencedirect.com/science/article/pii/S2090123222001710

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