High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion

Fucosylated glycosaminoglycan (FG) from sea cucumbers has been reported to have anticoagulant effects via targeting intrinsic tenase. However, FG from natural source also potentially poses risks due to its FXIIa activation and platelet aggregating effects. Here, we found that the effect of FG on hum...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Lisha Lin, Lian Yang, Jun Chen, Lutan Zhou, Sujuan Li, Na Gao, Jinhua Zhao
Format: Artikel
Sprache:English
Veröffentlicht: Taylor & Francis Group 2021-10-01
Schriftenreihe:Platelets
Schlagworte:
Online Zugang:http://dx.doi.org/10.1080/09537104.2020.1820976