Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis

Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis

Objective: The aim of this study was to develop a thermosensitive in situ gel (TISG) as an effective rectal delivery platform for delivering Periplaneta americana extracts (PA) to alleviate ulcerative colitis (UC) and explore the underlying molecular mechanism.Materials and methods: Thermosensitive...

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Bibliographic Details
Main Authors: Ming Wu, Hui Ding, Xiao Tang, Jiayi Chen, Meng Zhang, Ziqiong Yang, Qian Du, Jun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
Periplaneta americana
thermosensitive in situ gel
ulcerative colitis
rectal delivery
necroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1111267/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1111267/full

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