Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval.

Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval.

<h4>Background</h4>Chloride (Cl) secretion by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) located in the apical membrane of respiratory epithelial cells plays a critical role in maintenance of the airway surface liquid and mucociliary clearance of pathogens. Previously...

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Bibliographic Details
Main Authors: Jennifer M Bomberger, Bonita A Coutermarsh, Roxanna L Barnaby, J Denry Sato, M Christine Chapline, Bruce A Stanton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089599&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089599&type=printable

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