Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection

Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection

Abstract Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here, we find that, during the time frame of antigen archiving, LEC apoptosis caused by a second, but unrelated, i...

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Bibliographic Details
Main Authors: Thu A. Doan, Tadg S. Forward, Johnathon B. Schafer, Erin D. Lucas, Ira Fleming, Aspen Uecker-Martin, Edgardo Ayala, Jenna J. Guthmiller, Jay R. Hesselberth, Thomas E. Morrison, Beth A. Jirón Tamburini
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-00856-6

Internet

https://doi.org/10.1038/s41541-024-00856-6

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