The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia

The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia

T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogeneous with a wide range of clinical, morphological...

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Main Authors: Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Format: Article
Language:English
Published: Ferrata Storti Foundation 2021-02-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/10181

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https://haematologica.org/article/view/10181

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