Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through...

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Bibliographic Details
Main Authors: Semiramis A. Popova, Simon J. A. Buczacki
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2018.1494950