Novel homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia owing to dynein arm complex and mitochondrial sheath defects in flagella

Novel homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia owing to dynein arm complex and mitochondrial sheath defects in flagella

Introduction: Tracing the genetic causes for male infertility due to asthenoteratozoospermia has revealed at least 40 causative genes, which provides valuable reference for the genetic testing of asthenoteratozoospermia in clinical practice. To identify deleterious variants in the human tetratricope...

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Bibliographic Details
Main Authors: Lanlan Meng, Qiang Liu, Chen Tan, Xilin Xu, Wenbin He, Tongyao Hu, Chaofeng Tu, Yong Li, Juan Du, Qianjun Zhang, Guangxiu Lu, Li-Qing Fan, Ge Lin, Hongchuan Nie, Huan Zhang, Yue-Qiu Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
male infertility
TTC12
asthenoteratozoospermia
dynein arm complex defects
mitochondrial sheath malformations
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1184331/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1184331/full

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