Endogenous and Exogenous Glucocorticoids Prevent Trimethyltin From Causing Neuronal Degeneration of the Mouse Brain In vivo: Involvement of Oxidative Stress Pathways

Abstract.: The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy. However, no evaluation has been attempted to determine the mechanism underlying the enhancement of TM...

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Bibliographic Details
Main Authors: Makoto Shuto, Kei Higuchi, Chie Sugiyama, Masanori Yoneyama, Nobuyuki Kuramoto, Reiko Nagashima, Koichi Kawada, Kiyokazu Ogita
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319311491