Activation of the Nrf2 Pathway as a Therapeutic Strategy for ALS Treatment
Amyotrophic lateral sclerosis is a progressive and fatal disease that causes motoneurons degeneration and functional impairment of voluntary muscles, with limited and poorly efficient therapies. Alterations in the Nrf2-ARE pathway are associated with ALS pathology and result in aberrant oxidative st...
Main Authors: | Liaisan Arslanbaeva, Marco Bisaglia |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-02-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/5/1471 |
Similar Items
-
How Degeneration of Cells Surrounding Motoneurons Contributes to Amyotrophic Lateral Sclerosis
by: Roxane Crabé, et al.
Published: (2020-11-01) -
The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing
by: Aki Soejima-Kusunoki, et al.
Published: (2022-07-01) -
Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology
by: Yoshinobu Ichimura, et al.
Published: (2022-12-01) -
Dipeptide Repeat Pathology in <i>C9orf72</i>-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance
by: José Jiménez-Villegas, et al.
Published: (2022-09-01) -
AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury
by: Pauline Michel-Flutot, et al.
Published: (2022-08-01)