Antiproliferative and apoptotic activity of gemcitabine-lauric acid conjugate on human bladder cancer cells

Objective(s): Gemcitabine is a first-line drug for the treatment of bladder cancer. One of the most important mechanisms of gemcitabine resistance is the low expression of cellular membrane transporter hENT1. Various derivatives containing fatty acid side chains have been developed in order to facil...

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Bibliographic Details
Main Authors: Hongxia Wang, Zhiyu Shao, Zhiwen Xu, Binghao Ye, Ming Li, Qiaoqiao Zheng, Xingyuan Ma, Ping Shi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-04-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:https://ijbms.mums.ac.ir/article_20088_e423ed5179cc59bbfc8f69a34672a776.pdf