Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo

Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo

Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O-GlcNAc transferase (OGT), whereas O-GlcNAcase (OGA) enzyme is responsible for removal of this PTM. Previous work showed that OG...

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Bibliographic Details
Main Authors: Seokwon Jo, Samantha Pritchard, Alicia Wong, Nandini Avula, Ahmad Essawy, John Hanover, Emilyn U. Alejandro
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
O‐linked N‐acetylglucosamine (O‐GlcNAc)
O-GlcNAcylation
O-GlcNAcase (OGA)
beta cell (β‐cell)
insulin
insulin secretion
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1040014/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.1040014/full

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