Halogenated Dihydropyrrol-2-One Molecules Inhibit Pyocyanin Biosynthesis by Blocking the <i>Pseudomonas</i> Quinolone Signaling System

Halogenated Dihydropyrrol-2-One Molecules Inhibit Pyocyanin Biosynthesis by Blocking the <i>Pseudomonas</i> Quinolone Signaling System

Quorum-sensing (QS) systems of <i>Pseudomonas aeruginosa</i> are involved in the control of biofilm formation and virulence factor production. The current study evaluated the ability of halogenated <b>dihydropyrrol-2-ones (DHP) (Br (4a), Cl (4b), and F (4c))</b> and a non-hal...

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Bibliographic Details
Main Authors: Theerthankar Das, Shekh Sabir, Ren Chen, Jessica Farrell, Frederik H. Kriel, Gregory S. Whiteley, Trevor O. Glasbey, Jim Manos, Mark D. P. Willcox, Naresh Kumar
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
<i>P. aeruginosa</i>
pyocyanin
dihydropyrrol-2-one
LasR
PQS
quorum sensing
Online Access:https://www.mdpi.com/1420-3049/27/4/1169

Internet

https://www.mdpi.com/1420-3049/27/4/1169

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