Downregulation of Plasma Membrane Ca2+ ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons

Downregulation of Plasma Membrane Ca2+ ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons

In Drosophila melanogaster, several Gal4 drivers are used to direct gene/RNAi expression to different dopaminergic neuronal clusters. We previously developed a fly model of Parkinson’s disease, in which dopaminergic neurons had elevated cytosolic Ca2+ due to the expression of a Plasma Membrane Ca2+...

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Bibliographic Details
Main Authors: Brenda Erhardt, Lia Frenkel, María Silvina Marcora, María Isabel Farías, Carina Cintia Ferrari, Fernando Juan Pitossi, María Celeste Leal
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Fly
Subjects:
calcium
gut
flies
dopaminergic neurons
gal4-uas
gal80
Online Access:http://dx.doi.org/10.1080/19336934.2023.2192457

Internet

http://dx.doi.org/10.1080/19336934.2023.2192457

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