Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters

Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters

IntroductionAntibody therapeutic strategies have served an important role during the COVID-19 pandemic, even as their effectiveness has waned with the emergence of escape variants. Here we sought to determine the concentration of convalescent immunoglobulin required to protect against disease from S...

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Bibliographic Details
Main Authors: Hannah A. D. King, Vincent Dussupt, Letzibeth Mendez-Rivera, Bonnie M. Slike, Ursula Tran, Nathan D. Jackson, Erica Barkei, Michelle Zemil, Emily Tourtellott-Fogt, Caitlin H. Kuklis, Sandrine Soman, Aslaa Ahmed, Maciel Porto, Christopher Kitajewski, Brittany Spence, Dalia Benetiene, Lindsay Wieczorek, Swagata Kar, Gregory Gromowski, Victoria R. Polonis, Shelly J. Krebs, Kayvon Modjarrad, Diane L. Bolton
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
antibody
passive transfer
IgM
IgG
hamster
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138629/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138629/full

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