Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking

Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking

Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were replenished with FAs supplied by autophagy. These fi...

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Bibliographic Details
Main Authors: Sarah Cohen, Angelika S. Rambold, Jennifer Lippincott-Schwartz
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Molecular & Cellular Oncology
Subjects:
autophagy
fatty acid
lipase
lipid droplet
lipophagy
mfn1
mitochondria
opa1
tumor metabolism
tumor-stroma interactions
Online Access:http://dx.doi.org/10.1080/23723556.2015.1043038

Internet

http://dx.doi.org/10.1080/23723556.2015.1043038

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