Amylin receptor agonism enhances the effects of liraglutide in protecting against the acute metabolic side effects of olanzapine

Summary: Olanzapine is a second-generation antipsychotic (AP) used in the management of schizophrenia. Although effective at reducing psychoses, APs cause rapid hyperglycemia, insulin resistance, and dyslipidemia, an effect mediated in part by glucagon. We tested if amylin, a hormone that reduces gl...

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Bibliographic Details
Main Authors: Kyle D. Medak, Stewart Jeromson, Annalaura Bellucci, Meagan Arbeau, David C. Wright
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223027050