SIRT1/FOXO3-mediated autophagy signaling involved in manganese-induced neuroinflammation in microglia

SIRT1/FOXO3-mediated autophagy signaling involved in manganese-induced neuroinflammation in microglia

Manganese (Mn), as one of the environmental risk factors for Parkinson’s disease (PD), has been widely studied. Though autophagy dysfunction and neuroinflammation mainly are responsible for the causative issue of Mn neurotoxicity, the molecular mechanism of parkinsonism caused by Mn has not been exp...

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Bibliographic Details
Main Authors: Dongying Yan, Yuqing Yang, Jing Lang, Xiaobai Wang, Ying Huang, Jia Meng, Jie Wu, Xinning Zeng, Hong Li, Honglin Ma, Liang Gao
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Manganese
Neuroinflammation
Autophagy
Silent information regulator 1
Forkhead box O3
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323003767

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http://www.sciencedirect.com/science/article/pii/S0147651323003767

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