Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats
It was reported that the consumption of <i>Saccharina japonica</i> (SJ) lowers blood pressure (BP) in hypertensive rats. Hypertension is related to gut microbiota, and hypertensive patients develop dysbiosis. It was reported that the intake of dietary fiber and polysaccharides contained...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/3/556 |
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| author | Ayaka Harui Saki Maruyama Yukiko Segawa Nobutaka Kurihara |
| author_facet | Ayaka Harui Saki Maruyama Yukiko Segawa Nobutaka Kurihara |
| author_sort | Ayaka Harui |
| collection | DOAJ |
| description | It was reported that the consumption of <i>Saccharina japonica</i> (SJ) lowers blood pressure (BP) in hypertensive rats. Hypertension is related to gut microbiota, and hypertensive patients develop dysbiosis. It was reported that the intake of dietary fiber and polysaccharides contained in SJ changes gut microbiota and increases short-chain fatty acids (SCFAs). The present study examined the effect of BP lowering by SJ in spontaneously hypertensive rats (SHRs) and observed changes in gut microbiota composition and SCFAs concentration. Male SHRs and Wistar Kyoto rats (WKYs) were fed a diet containing 5% SJ or a control diet for six weeks. We measured systolic BP (SBP) weekly, as well as mean arterial BP (MAP), the 16S rRNA gene, and SCFAs in the cecal contents at the end of the period. As a result, the intake of SJ significantly decreased SBP and MAP in SHRs. As well, it significantly changed the microbial diversity by altering the gut microbiota composition. Particularly, it increased the abundance of <i>Bacteroides acidifaciens</i>, which may be associated with the antihypertensive effect of SJ. Thus, SJ intake suppressed the increase in BP and altered the gut microbiota composition, although it did not significantly change the SCFAs concentration in the cecal contents. |
| first_indexed | 2024-04-24T17:59:45Z |
| format | Article |
| id | doaj.art-c538a98f72c64962a2e1284b04ef7cb8 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-04-24T17:59:45Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-c538a98f72c64962a2e1284b04ef7cb82024-03-27T13:55:49ZengMDPI AGMicroorganisms2076-26072024-03-0112355610.3390/microorganisms12030556Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive RatsAyaka Harui0Saki Maruyama1Yukiko Segawa2Nobutaka Kurihara3Hygiene and Preventive Medicine, Graduate School of Home Economics, Kobe Women’s University, 2-1 Higashisuma-Aoyama, Suma, Kobe 654-8585, JapanHygiene and Preventive Medicine, Graduate School of Home Economics, Kobe Women’s University, 2-1 Higashisuma-Aoyama, Suma, Kobe 654-8585, JapanHygiene and Preventive Medicine, Graduate School of Home Economics, Kobe Women’s University, 2-1 Higashisuma-Aoyama, Suma, Kobe 654-8585, JapanHygiene and Preventive Medicine, Graduate School of Home Economics, Kobe Women’s University, 2-1 Higashisuma-Aoyama, Suma, Kobe 654-8585, JapanIt was reported that the consumption of <i>Saccharina japonica</i> (SJ) lowers blood pressure (BP) in hypertensive rats. Hypertension is related to gut microbiota, and hypertensive patients develop dysbiosis. It was reported that the intake of dietary fiber and polysaccharides contained in SJ changes gut microbiota and increases short-chain fatty acids (SCFAs). The present study examined the effect of BP lowering by SJ in spontaneously hypertensive rats (SHRs) and observed changes in gut microbiota composition and SCFAs concentration. Male SHRs and Wistar Kyoto rats (WKYs) were fed a diet containing 5% SJ or a control diet for six weeks. We measured systolic BP (SBP) weekly, as well as mean arterial BP (MAP), the 16S rRNA gene, and SCFAs in the cecal contents at the end of the period. As a result, the intake of SJ significantly decreased SBP and MAP in SHRs. As well, it significantly changed the microbial diversity by altering the gut microbiota composition. Particularly, it increased the abundance of <i>Bacteroides acidifaciens</i>, which may be associated with the antihypertensive effect of SJ. Thus, SJ intake suppressed the increase in BP and altered the gut microbiota composition, although it did not significantly change the SCFAs concentration in the cecal contents.https://www.mdpi.com/2076-2607/12/3/556<i>Saccharina japonica</i>antihypertensive effectgut microbiota |
| spellingShingle | Ayaka Harui Saki Maruyama Yukiko Segawa Nobutaka Kurihara Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats Microorganisms <i>Saccharina japonica</i> antihypertensive effect gut microbiota |
| title | Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats |
| title_full | Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats |
| title_fullStr | Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats |
| title_full_unstemmed | Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats |
| title_short | Effect of <i>Saccharina japonica</i> Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats |
| title_sort | effect of i saccharina japonica i intake on blood pressure and gut microbiota composition in spontaneously hypertensive rats |
| topic | <i>Saccharina japonica</i> antihypertensive effect gut microbiota |
| url | https://www.mdpi.com/2076-2607/12/3/556 |
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