Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle

Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle

Type 2 diabetes mellitus (T2D) affects millions of people worldwide and is one of the leading causes of morbidity and mortality. The skeletal muscle (SKM) is one of the most important tissues involved in maintaining glucose homeostasis and substrate oxidation, and it undergoes insulin resistance in...

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Bibliographic Details
Main Authors: Iliana López-Soldado, Adrian Gabriel Torres, Raúl Ventura, Inma Martínez-Ruiz, Angels Díaz-Ramos, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzysztof Wanic, Declan O'Hanlon, Donal J. O'Gorman, Teresa Carbonell, Lluís Ribas de Pouplana, John J. Nolan, Antonio Zorzano, María Isabel Hernández-Alvarez
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Redox Biology
Subjects:
Type 2 diabetes
Mitochondrial aminoacyl tRNA synthetases
Nitrosative stress
OXPHOS
Skeletal muscle
Nitric oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000319

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http://www.sciencedirect.com/science/article/pii/S2213231723000319

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