Methoxymethyl (MOM) Group Nitrogen Protection of Pyrimidines Bearing C-6 Acyclic Side-Chains

Methoxymethyl (MOM) Group Nitrogen Protection of Pyrimidines Bearing C-6 Acyclic Side-Chains

Novel N-methoxymethylated (MOM) pyrimidine (4-13) and pyrimidine-2,4-diones (15-17) nucleoside mimetics in which an isobutyl side-chain is attached at the C-6 position of the pyrimidine moiety were synthesized. Synthetic methods via O-persilylated or N-anionic uracil derivatives have been evaluated...

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Bibliographic Details
Main Authors: Janez Plavec, Tobias L. Ross, Simon M. Ametamey, Silvana Raić-Malić, Damjan Makuc, Martina Petrović, Svjetlana Krištafor, Tatjana Gazivoda Kraljević
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Molecules
Subjects:
N-methoxymethyl protecting group
C-6 isobutyl pyrimidine derivatives
N-1 and N-3 regioisomers
NOE experiments
positron emission tomography (PET)
Online Access:http://www.mdpi.com/1420-3049/16/6/5113/

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http://www.mdpi.com/1420-3049/16/6/5113/

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