Anticalin N- or C-Terminal on a Monoclonal Antibody Affects Both Production and In Vitro Functionality

Anticalin N- or C-Terminal on a Monoclonal Antibody Affects Both Production and In Vitro Functionality

Bispecific antibodies (BsAbs) represent an important advance in innovative therapeutic strategies. Among the countless formats of BsAbs, fusion with molecules such as anticalins linked to a monoclonal antibody (mAb), represents an easy and low-cost way to obtain innovative molecules. We fused an ant...

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Bibliographic Details
Main Authors: Nicolas Aubrey, Valérie Gouilleux-Gruart, Christine Dhommée, Julie Mariot, Fanny Boursin, Nicolas Albrecht, Cécile Bergua, Cécile Croix, Mäelle Gilotin, Eloi Haudebourg, Catherine Horiot, Laetitia Matthias, Caroline Mouline, Laurie Lajoie, Audrey Munos, Gilles Ferry, Marie-Claude Viaud-Massuard, Gilles Thibault, Florence Velge-Roussel
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antibodies
Subjects:
monoclonal antibody
bispecific antibody
anticalin
Fc gamma receptors
FcRn
CD16
Online Access:https://www.mdpi.com/2073-4468/11/3/54

Internet

https://www.mdpi.com/2073-4468/11/3/54

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