Evaluation of Solvent Compatibilities for Headspace-SIFT-MS Analysis of Pharmaceutical Products

Evaluation of Solvent Compatibilities for Headspace-SIFT-MS Analysis of Pharmaceutical Products

Procedures for determination of the residual solvent and volatile impurity content in pharmaceutical products usually rely on dissolution in a solvent, followed by headspace-gas chromatography (HS-GC) analysis. Whereas chromatographic systems can utilize a wide variety of solvents, direct-injection...

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Bibliographic Details
Main Authors: Mark J. Perkins, Leslie P. Silva, Vaughan S. Langford
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Analytica
Subjects:
SIFT-MS
selected ion flow tube mass spectrometry
DIMS
residual solvents
headspace analysis
high-throughput analysis
Online Access:https://www.mdpi.com/2673-4532/4/3/24

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https://www.mdpi.com/2673-4532/4/3/24

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