Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease

Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease

Abstract Objective Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical role in protecting podocytes in DKD, is mainly expressed in kidney tubula...

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Bibliographic Details
Main Authors: Wei Jiang, Chun Gan, Xindi Zhou, Qing Yang, Dan Chen, Han Xiao, Lujun Dai, Yaxi Chen, Mo Wang, Haiping Yang, Qiu Li
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cardiovascular Diabetology
Subjects:
DKD
Klotho
ox-LDL deposition
Podocyte injury
IGF-1R
RAC1
Online Access:https://doi.org/10.1186/s12933-023-02025-w

Internet

https://doi.org/10.1186/s12933-023-02025-w

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