Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in <i>Atp8b1</i> Mutant Mouse Model of Pulmonary Fibrosis

Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in <i>Atp8b1</i> Mutant Mouse Model of Pulmonary Fibrosis

Abnormalities in airway epithelia and lung parenchyma are found in <i>Atp8b1</i> mutant mice, which develop pulmonary fibrosis after hyperoxic insult. Microarray and ingenuity pathway analysis (IPA) show numerous transcripts involved in ciliogenesis are downregulated in 14-month (14 M) -...

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Bibliographic Details
Main Authors: Emma Westermann-Clark, Ramani Soundararajan, Jutaro Fukumoto, Sahebgowda Sidramagowda Patil, Timothy M. Stearns, Smita Saji, Alexander Czachor, Helena Hernandez-Cuervo, Mason Breitzig, Sudarshan Krishnamurthy, Richard F. Lockey, Narasaiah Kolliputi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomolecules
Subjects:
idiopathic pulmonary fibrosis
<i>Atp8b1</i> mutant
MMP7
apical
ciliogenesis
Online Access:https://www.mdpi.com/2218-273X/12/2/283

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https://www.mdpi.com/2218-273X/12/2/283

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