Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and...

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Bibliographic Details
Main Authors: Michael Saitakis, Stéphanie Dogniaux, Christel Goudot, Nathalie Bufi, Sophie Asnacios, Mathieu Maurin, Clotilde Randriamampita, Atef Asnacios, Claire Hivroz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
T lymphocyte
rigidity
TCR
Online Access:https://elifesciences.org/articles/23190

Internet

https://elifesciences.org/articles/23190

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