Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blocking therapy has become a major pillar of cancer immunotherapy. Compared with antibodies targeting, small-molecule checkpoint inhibitors which have favorable pharmacokinetics are urgently needed. Here we identified berberine (...

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Bibliographic Details
Main Authors: Yang Liu, Xiaojia Liu, Na Zhang, Mingxiao Yin, Jingwen Dong, Qingxuan Zeng, Genxiang Mao, Danqing Song, Lu Liu, Hongbin Deng
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
PD-L1
Immune checkpoint blockade
COP9 signalosome 5
Berberine
PD-1/PD-L1 axis
T-cell immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306249

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http://www.sciencedirect.com/science/article/pii/S2211383520306249

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