Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin

Abstract Vitamin B12 (VB12) deficiency, which may lead to hematologic and neurologic symptoms, has been associated with metformin use, but the underlying mechanism is unclear. Here we report the B. ovatus as an effective VB12 catcher which was enriched in the type 2 diabetes patients suffered from V...

Full description

Bibliographic Details
Main Authors: Manyun Chen, Yan Shu, Qing Li, Zhiqiang Kang, Tao Liu, Honghao Zhou, Weihua Huang, Wei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-023-00419-y