Transforming growth factor-β in tumour development
Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function, and tissue repair following injury. Aberrant TGF...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.991612/full |
| _version_ | 1811229760766869504 |
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| author | Charles B. Trelford Lina Dagnino Lina Dagnino Gianni M. Di Guglielmo |
| author_facet | Charles B. Trelford Lina Dagnino Lina Dagnino Gianni M. Di Guglielmo |
| author_sort | Charles B. Trelford |
| collection | DOAJ |
| description | Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function, and tissue repair following injury. Aberrant TGFβ signalling has been implicated in tumour progression and metastasis. Tumour cells, in conjunction with their microenvironment, may augment tumourigenesis using TGFβ to induce epithelial-mesenchymal transition, angiogenesis, lymphangiogenesis, immune suppression, and autophagy. Therapies that target TGFβ synthesis, TGFβ-TGFβ receptor complexes or TGFβ receptor kinase activity have proven successful in tissue culture and in animal models, yet, due to limited understanding of TGFβ biology, the outcomes of clinical trials are poor. Here, we review TGFβ signalling pathways, the biology of TGFβ during tumourigenesis, and how protein quality control pathways contribute to the tumour-promoting outcomes of TGFβ signalling. |
| first_indexed | 2024-04-12T10:19:32Z |
| format | Article |
| id | doaj.art-c54c17d16b7948e2b8421793bbb91110 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-12T10:19:32Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-c54c17d16b7948e2b8421793bbb911102022-12-22T03:37:08ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-10-01910.3389/fmolb.2022.991612991612Transforming growth factor-β in tumour developmentCharles B. Trelford0Lina Dagnino1Lina Dagnino2Gianni M. Di Guglielmo3Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaDepartment of Oncology, Children’s Health Research Institute and Lawson Health Research Institute, London, ON, CanadaDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaTransforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function, and tissue repair following injury. Aberrant TGFβ signalling has been implicated in tumour progression and metastasis. Tumour cells, in conjunction with their microenvironment, may augment tumourigenesis using TGFβ to induce epithelial-mesenchymal transition, angiogenesis, lymphangiogenesis, immune suppression, and autophagy. Therapies that target TGFβ synthesis, TGFβ-TGFβ receptor complexes or TGFβ receptor kinase activity have proven successful in tissue culture and in animal models, yet, due to limited understanding of TGFβ biology, the outcomes of clinical trials are poor. Here, we review TGFβ signalling pathways, the biology of TGFβ during tumourigenesis, and how protein quality control pathways contribute to the tumour-promoting outcomes of TGFβ signalling.https://www.frontiersin.org/articles/10.3389/fmolb.2022.991612/fulltransforming growth factor-b (TGFb)Smadreceptor traffickingepithelial-mesenchymal transition (EMT)autophagyprotein 62/sequestosome 1 (p62/SQSTM1) |
| spellingShingle | Charles B. Trelford Lina Dagnino Lina Dagnino Gianni M. Di Guglielmo Transforming growth factor-β in tumour development Frontiers in Molecular Biosciences transforming growth factor-b (TGFb) Smad receptor trafficking epithelial-mesenchymal transition (EMT) autophagy protein 62/sequestosome 1 (p62/SQSTM1) |
| title | Transforming growth factor-β in tumour development |
| title_full | Transforming growth factor-β in tumour development |
| title_fullStr | Transforming growth factor-β in tumour development |
| title_full_unstemmed | Transforming growth factor-β in tumour development |
| title_short | Transforming growth factor-β in tumour development |
| title_sort | transforming growth factor β in tumour development |
| topic | transforming growth factor-b (TGFb) Smad receptor trafficking epithelial-mesenchymal transition (EMT) autophagy protein 62/sequestosome 1 (p62/SQSTM1) |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.991612/full |
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