A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer

A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer

The oncogenic expression or mutation of tumor suppressors drives metabolic alteration, causing cancer cells to utilize diverse nutrients. Lactate is a known substrate for cancer cells, yet the regulatory mechanisms of lactate catabolism are limited. Here, we show that a heme-binding transcription fa...

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Bibliographic Details
Main Authors: Joselyn Padilla, Bok-Soon Lee, Karen Zhai, Bethany Rentz, Tia Bobo, Norca Maritza Dowling, Jiyoung Lee
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
lactate catabolism
BACH1
lactate transporter
novel combination therapy targeting BACH1 and MCT1
triple-negative breast cancer
Online Access:https://www.mdpi.com/2073-4409/11/7/1177

Internet

https://www.mdpi.com/2073-4409/11/7/1177

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