QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition

QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition

Background/Objectives: HMG-CoA reductase is an enzyme that regulates the initial stage of cholesterol synthesis, and its inhibitors are widely used in the treatment of cardiovascular diseases. Methods: We have created a set of quantitative structure-activity relationship (QSAR) models for human HMG-...

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Bibliographic Details
Main Authors: Robert Ancuceanu, Patriciu Constantin Popovici, Doina Drăgănescu, Ștefan Busnatu, Beatrice Elena Lascu, Mihaela Dinu
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceuticals
Subjects:
HMG-CoA reductase
QSAR
statins
nested cross-validation
virtual screening
<i>Iris germanica</i>
Online Access:https://www.mdpi.com/1424-8247/17/11/1448

Internet

https://www.mdpi.com/1424-8247/17/11/1448

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