A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can gi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04441-z |
| _version_ | 1819195293761011712 |
|---|---|
| author | Keisuke Sumide Yoshikazu Matsuoka Hiroshi Kawamura Ryusuke Nakatsuka Tatsuya Fujioka Hiroaki Asano Yoshihiro Takihara Yoshiaki Sonoda |
| author_facet | Keisuke Sumide Yoshikazu Matsuoka Hiroshi Kawamura Ryusuke Nakatsuka Tatsuya Fujioka Hiroaki Asano Yoshihiro Takihara Yoshiaki Sonoda |
| author_sort | Keisuke Sumide |
| collection | DOAJ |
| description | Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can give rise to erythroid megakaryocytic progenitors. |
| first_indexed | 2024-12-23T02:10:28Z |
| format | Article |
| id | doaj.art-c550f20a25a54ac691d698a7862e3926 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:10:28Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c550f20a25a54ac691d698a7862e39262022-12-21T18:03:48ZengNature PortfolioNature Communications2041-17232018-06-019111710.1038/s41467-018-04441-zA revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cellsKeisuke Sumide0Yoshikazu Matsuoka1Hiroshi Kawamura2Ryusuke Nakatsuka3Tatsuya Fujioka4Hiroaki Asano5Yoshihiro Takihara6Yoshiaki Sonoda7Department of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical UniversitySchool of Nursing, Kyoto Prefectural University of MedicineDepartment of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical UniversitySingle CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can give rise to erythroid megakaryocytic progenitors.https://doi.org/10.1038/s41467-018-04441-z |
| spellingShingle | Keisuke Sumide Yoshikazu Matsuoka Hiroshi Kawamura Ryusuke Nakatsuka Tatsuya Fujioka Hiroaki Asano Yoshihiro Takihara Yoshiaki Sonoda A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells Nature Communications |
| title | A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells |
| title_full | A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells |
| title_fullStr | A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells |
| title_full_unstemmed | A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells |
| title_short | A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells |
| title_sort | revised road map for the commitment of human cord blood cd34 negative hematopoietic stem cells |
| url | https://doi.org/10.1038/s41467-018-04441-z |
| work_keys_str_mv | AT keisukesumide arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT yoshikazumatsuoka arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT hiroshikawamura arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT ryusukenakatsuka arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT tatsuyafujioka arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT hiroakiasano arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT yoshihirotakihara arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT yoshiakisonoda arevisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT keisukesumide revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT yoshikazumatsuoka revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT hiroshikawamura revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT ryusukenakatsuka revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT tatsuyafujioka revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT hiroakiasano revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT yoshihirotakihara revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells AT yoshiakisonoda revisedroadmapforthecommitmentofhumancordbloodcd34negativehematopoieticstemcells |