Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal

Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal

A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal CTD-CAF showed a supramolecular organization in which CAF m...

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Bibliographic Details
Main Authors: Christian Rodríguez-Ruiz, Pedro Montes-Tolentino, Jorge Guillermo Domínguez-Chávez, Hugo Morales-Rojas, Herbert Höpfl, Dea Herrera-Ruiz
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
chlorthalidone
pharmaceutical cocrystal
solubility and dissolution studies
cellulosic polymer
X-ray diffraction analysis
Online Access:https://www.mdpi.com/1999-4923/14/2/334

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https://www.mdpi.com/1999-4923/14/2/334

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