Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

The induction of immunogenic cell death (ICD) can potentiate antitumour immunity. Here the authors show that USP18, a negative regulator of IFN signaling protects cancer cells from ICD by suppressing the expression of canonical and non-canonical IFN-stimulated genes.

Bibliographic Details
Main Authors: Kei-ichiro Arimoto, Sayuri Miyauchi, Ty D. Troutman, Yue Zhang, Mengdan Liu, Samuel A. Stoner, Amanda G. Davis, Jun-Bao Fan, Yi-Jou Huang, Ming Yan, Christopher K. Glass, Dong-Er Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35348-5

Internet

https://doi.org/10.1038/s41467-022-35348-5

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