Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
The induction of immunogenic cell death (ICD) can potentiate antitumour immunity. Here the authors show that USP18, a negative regulator of IFN signaling protects cancer cells from ICD by suppressing the expression of canonical and non-canonical IFN-stimulated genes.
Bibliographic Details
| Main Authors: |
Kei-ichiro Arimoto,
Sayuri Miyauchi,
Ty D. Troutman,
Yue Zhang,
Mengdan Liu,
Samuel A. Stoner,
Amanda G. Davis,
Jun-Bao Fan,
Yi-Jou Huang,
Ming Yan,
Christopher K. Glass,
Dong-Er Zhang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-35348-5
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