Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging

Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging

Abstract Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual-polarity ionization mass spectrometry imaging (MSI) to enable high-throughput in situ profiling of the SC lipido...

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Bibliographic Details
Main Authors: Hua Zhang, Yuan Liu, Lauren Fields, Xudong Shi, Penghsuan Huang, Haiyan Lu, Andrew J. Schneider, Xindi Tang, Luigi Puglielli, Nathan V. Welham, Lingjun Li
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40512-6

Internet

https://doi.org/10.1038/s41467-023-40512-6

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