Charged Residue Implantation Improves the Affinity of a Cross-Reactive Dengue Virus Antibody

Charged Residue Implantation Improves the Affinity of a Cross-Reactive Dengue Virus Antibody

Dengue virus (DENV) has four serotypes that complicate vaccine development. Envelope protein domain III (EDIII) of DENV is a promising target for therapeutic antibody development. One EDIII-specific antibody, dubbed 1A1D-2, cross-reacts with DENV 1, 2, and 3 but not 4. To improve the affinity of 1A1...

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Bibliographic Details
Main Authors: Huiling Wei, Jie Tan, Bingjie Zhou, Xiaotong Guan, Qiaoxian Zhong, Jiaqi Wang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
cross-reactive antibody
dengue virus
affinity maturation
charge complementarity
molecular dynamics simulation
Online Access:https://www.mdpi.com/1422-0067/23/8/4197

Internet

https://www.mdpi.com/1422-0067/23/8/4197

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