PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection

PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection

Abstract Peptidoglycan recognition proteins (PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. Here we show that PGLYRP1 is a receptor for the disaccharide m...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Shuyuan Chen, Rachel Putnik, Xi Li, Alka Diwaker, Marina Vasconcelos, Shuzhen Liu, Sudershan Gondi, Junhui Zhou, Lei Guo, Lin Xu, Sebastian Temme, Klare Bersch, Stephen Hyland, Jianyi Yin, Ezra Burstein, Brian J. Bahnson, Jeffrey C. Gildersleeve, Catherine Leimkuhler Grimes, Hans-Christian Reinecker
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Nature Portfolio 2025-02-01
Sarja:Nature Communications
Linkit:https://doi.org/10.1038/s41467-025-57126-9

Internet

https://doi.org/10.1038/s41467-025-57126-9

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