Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screening

Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screening

The key structure of the interface between the spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human angiotensin-converting enzyme 2 (hACE2) acts as an essential switch for cell entry by the virus and drugs targets. However, this is largely unknown. Here, we tested...

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Bibliographic Details
Main Authors: Xiaopeng Hu, Jiahua Cui, Jun Chen, Shujuan Du, Xinyu Wang, Yabin Zhang, Jiajun Qian, Haifeng Chen, Fang Wei, Qiliang Cai, Jinping Jia, Ji Wu
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Virus Research
Subjects:
SARS-CoV-2
RBD
binding sites
Cephalosporin derivative
Cefixime
Ceftazidime
Online Access:http://www.sciencedirect.com/science/article/pii/S016817022200243X

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http://www.sciencedirect.com/science/article/pii/S016817022200243X

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