MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome

MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome

Abstract Sturge-Weber syndrome (SWS), a neurocutaneous disorder, is characterized by capillary malformations (CM) in the skin, brain, and eyes. Patients may suffer from seizures, strokes, and glaucoma, and only symptomatic treatment is available. CM are comprised of enlarged vessels with endothelial...

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Bibliographic Details
Main Authors: Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Sanda Alexandrescu, Anna Pinto, Arin K. Greene, Donald E. Ingber, Joyce Bischoff
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Acta Neuropathologica Communications
Subjects:
Capillary malformation
GNAQ
Sturge Weber syndrome
Vascular malformation
Macrophages
Leukocyte adhesion
Online Access:https://doi.org/10.1186/s40478-024-01757-4

Internet

https://doi.org/10.1186/s40478-024-01757-4

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