Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Abstract Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on the pharmacokinetics of metoprolol i...

Full description

Bibliographic Details
Main Authors: Ravindra Babu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Vijaya R. Dirisala, Harsha Sai Chanumolu, Naveen Babu Kilaru
Format: Article
Language:English
Published: SpringerOpen 2023-01-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Metoprolol
Hesperetin
CYP3A4
CYP2C9
P-glycoprotein
Online Access:https://doi.org/10.1186/s43094-022-00457-x

Internet

https://doi.org/10.1186/s43094-022-00457-x

Similar Items