<i>TP53</i> Pathogenic Variants in Early-Onset Breast Cancer Patients Fulfilling Hereditary Breast and Ovary Cancer and Li-Fraumeni-like Syndromes

<i>TP53</i> Pathogenic Variants in Early-Onset Breast Cancer Patients Fulfilling Hereditary Breast and Ovary Cancer and Li-Fraumeni-like Syndromes

<i>TP53</i> gene mutation is the most common genetic alteration in human malignant tumors and is mainly responsible for Li-Fraumeni syndrome. Among the several cancers related to this syndrome, breast cancer (BC) is the most common. The <i>TP53</i> p.R337H germline pathogenic...

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Bibliographic Details
Main Authors: Paula Francinete Faustino da Silva, Rebeca Mota Goveia, Thaís Bomfim Teixeira, Bruno Faulin Gamba, Aliny Pereira de Lima, Sílvia Regina Rogatto, Elisângela de Paula Silveira-Lacerda
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomolecules
Subjects:
<i>TP53</i>
breast cancer
Li-Fraumeni syndrome
cancer predisposition
Online Access:https://www.mdpi.com/2218-273X/12/5/640

Internet

https://www.mdpi.com/2218-273X/12/5/640

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