Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

Abstract Background ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer’s disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits...

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Bibliographic Details
Main Authors: Sofía Fernández de Retana, Paula Marazuela, Montse Solé, Guillem Colell, Anna Bonaterra, Jose Luis Sánchez-Quesada, Joan Montaner, Daniel Maspoch, Mary Cano-Sarabia, Mar Hernández-Guillamon
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Clusterin
Apolipoprotein J
ApoJ
APP23
Reconstituted HDL
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13195-019-0498-8

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http://link.springer.com/article/10.1186/s13195-019-0498-8

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