Influence of cytochrome P450 2D6*10/*10 genotype on the risk for tramadol associated adverse effects: a retrospective cohort study

Influence of cytochrome P450 2D6*10/*10 genotype on the risk for tramadol associated adverse effects: a retrospective cohort study

Background: Tramadol is primarily metabolized by the highly polymorphic CYP2D6 enzyme, leading to a large spectrum of adverse events and clinical response. Ample evidence pointed a reduced CYPD26 activity score in individuals harboring the CYP2D6*10/*10 genotype, nevertheless, there is scarce studie...

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Bibliographic Details
Main Authors: Mahmood Mahajna, Rami Abu Fanne, Mahmoud Odeh, Matitiahu Berkovitch, Elias Tannous, Sara Eyal, Shlomo Vinker, Ilan Green, Ilan Matok
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
CYP2D6
database
O-desmethyltramadol
polymorphism
tramadol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1358549/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1358549/full

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