Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes

Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes

Glucocorticoids such as dexamethasone (Dex) are widely used to treat both acute and chronic inflammatory conditions. They regulate immune responses by dampening cell-mediated immunity in a glucocorticoid receptor (GR)-dependent manner, by suppressing the expression of pro-inflammatory cytokines and...

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Bibliographic Details
Main Authors: Suhail A. Ansari, Widad Dantoft, Jorge Ruiz-Orera, Afzal P. Syed, Susanne Blachut, Sebastiaan van Heesch, Norbert Hübner, Nina Henriette Uhlenhaut
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Glucocorticoid receptor
Macrophages
Inflammation
Ribosome profiling
RNA-seq
Translational regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004470

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http://www.sciencedirect.com/science/article/pii/S2001037022004470

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