Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma

Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma

Mantle Cell Lymphoma (MCL) is still an incurable B-cell malignancy characterized by poor prognosis and frequent relapses. B Cell Receptor (BCR) signaling inhibitors, in particular of the kinases BTK and PI3Kγ/δ, have demonstrated clinically meaningful anti-proliferative effects in B cell tumors. How...

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Bibliographic Details
Main Authors: Sabrina Manni, Anna Fregnani, Laura Quotti Tubi, Zaira Spinello, Marco Carraro, Greta Scapinello, Andrea Visentin, Gregorio Barilà, Marco Pizzi, Angelo Paolo Dei Tos, Fabrizio Vianello, Renato Zambello, Carmela Gurrieri, Gianpietro Semenzato, Livio Trentin, Francesco Piazza
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
mantle cell lymphoma
CK1α
BCR inhibitors
ibrutinib
duvelisib
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.733848/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.733848/full

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